CCMB and SCI hold hands to challenge sickle cell anaemia
Centre for Cellular and Molecular Biology (CCMB) and the Sickle Cell Institute, Chhattisgarh (SCIC), Raipur have joined hands to tackle sickle cell anaemia.
In Chhattisgarh, around 10 for every penny of the 15 lakh people screened under a state venture have been observed to be carriers of the sickness, as per Pradeep K Patra, Director-General, SCIC.
CCMB and SCIC will cooperate to recognize eligible carrier couples who are at the danger of bringing forth an influenced youngster and tail them with genetic testing, pre-birth conclusion and genetic guiding.
Sickle-cell disease (SCD) is a group of genetically passed down blood disorders. The most common type is known as sickle-cell anaemia (SCA). It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. This leads to a rigid, sickle-like shape under certain circumstances.Problems in sickle cell disease typically begin around 5 to 6 months of age. A number of health problems may develop, such as attacks of pain (“sickle-cell crisis”), anemia, bacterial infections, and stroke.Long term pain may develop as people get older. The average life expectancy in the developed world is 40 to 60 years.In short Sickle cell anaemia is a serious disorder of haemoglobin and is widely prevalent in the states of Chhattisgarh, Maharashtra, Gujarat, and Orissa and sparingly in other places. It is an inherited form of anemia — a condition in which there aren’t enough healthy red blood cells to carry adequate oxygen throughout the body of an individual.
The disease occurs globally due to a single mutation in the beta globin gene and follows an autosomal recessive pattern of inheritance meaning that parents are usually the carriers of the defective gene and the disease occurs when both copies of it are inherited together by the children.
As per an MOU signed at CCMB, the partnership will see the combination of the clinical expertise of SCIC with the molecular biology expertise and genetic testing experience of CSIR-CCMB. The primary focus will be to strive to reduce the burden of sickle cell anemia in the State of Chhattisgarh.
Rakesh Mishra, Director, CSIR-CCMB, said “ We are committed to reduce the societal burden of sickle cell anemia in India and countries like Cyprus and Sardinia have already been successful in the near abolition of risk of hemoglobinopathies by such collaborations of scientists and clinicians.”
He said both institutes will also conduct research to identify molecular markers to understand the molecular basis of these differences and thus help identify newer management strategies and eventually a therapy for the disease.