Gut bacteria improve type 2 diabetes risk prediction
The microbial composition of the intestines is complex and varies widely from one individual to another. Many factors such as environmental factors, lifestyle, genetics or illnesses affect the intestinal ecosystem of helpful gut bacteria.
Dirk Haller, Professor for Nutrition and Immunology at TUM, and his team have examined the importance of daytime-dependent fluctuations of the gut microbiome in relation to type 2 diabetes; they present their study encompassing more than 4000 people and it is the first study in this field based on a large prospective human cohort.
The relationship between gut bacteria and medical conditions “In order to see whether changes in the gut microbiome allow conclusions about medical conditions, so-called prospective cohort studies are required,” explained Prof. Haller.
In these prospective cohort studies, a cross section of the population is being observed; however, none of the participants showed any signs of disease. This population is being re-examined over time. This way, researchers can find out whether a certain observation may be typical for future occurrences of diseases.
Diagnosis and outlook of type 2 diabetes may be improved “When certain gut bacteria do not follow a day-night rhythm, so if their number and function does not change over the course of the day, this can be an indicator for a potential type 2 diabetes disease. Knowing this can improve diagnosis and outlook of type 2 diabetes,” said Chronobiologist Dr. Silke Kiessling, another contributor to the study.
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